PBPK相关论文
背景：长期低剂量的镉暴露会导致肾损伤、骨密度降低、心血管疾病等不良结局。镉的膳食暴露来源是普通非吸烟人群的主要暴露途径，已被......
Physiologically based pharmacokinetic(PBPK) modeling and simulation can be used to predict the pharmacokinetic behavior ......
Dose selection of chloroquine phosphate for treatment of COVID-19 based on a physiologically based p
Chloroquine (CQ) phosphate has been suggested to be clinically effective in the treatment of coronavirus disease 2019 (C......
实验通过建立鼠的三聚氰胺动力学模型(PBPK),拓展出猪的PBPK模型,从而确定适当的停药时间.结果表明:鼠模型低估了血浆中三聚氰胺的......
基于传统低阶线性房室药代动力学模型的TCI，可以用解析方法求解所需的给药曲线。但是，基于生理药代动力学模型的TCI，因其数学描述一般......
In the development of new drugs as well as new formulations of existing products(including generic products),it is of gr......
作为乳腺癌治疗的一线药物,曲妥珠单抗在临床的应用显著延长了人表皮生长因子受体 2(Human epidermal growth factor 2,Her2)阳性......
由于理化及生物学性质的差异,生物大分子药物与传统小分子药物相比,药代动力学机制更加复杂,在体内表现出不同的吸收、分布、代谢......
